• Bloodstream infections and sepsis in Greece: Over-time change of epidemiology and impact of de-escalation on final outcome 

      Koupetori, M.; Retsas, T.; Antonakos, N.; Vlachogiannis, G.; Perdios, I.; Nathanail, C.; Makaritsis, K.; Papadopoulos, A.; Sinapidis, D.; Giamarellos-Bourboulis, E. J.; Pneumatikos, I.; Gogos, C.; Armaganidis, A.; Paramythiotou, E. (2014)
      Background: Choice of empirically prescribed antimicrobials for sepsis management depends on epidemiological factors. The epidemiology of sepsis in Greece was studied in two large-periods.Methods: Sepsis due to bloodstream ...
    • Ceftazidime-avibactam to treat life-threatening infections by carbapenem-resistant pathogens in critically ill mechanically ventilated patients 

      Tsolaki V., Mantzarlis K., Mpakalis A., Malli E., Tsimpoukas F., Tsirogianni A., Papagiannitsis C., Zygoulis P., Papadonta M.-E., Petinaki E., Makris D., Zakynthinos E. (2020)
      Data on the effectiveness of ceftazidime-avibactam (CAZ-AVI) in critically ill, mechanically ventilated patients are limited. The present retrospective observational cohort study, which was conducted in two general intensive ...
    • Ceftazidime/avibactam in the era of carbapenemase-producing Klebsiella pneumoniae: Experience from a national registry study 

      Karaiskos I., ikaraiskos@hygeia.gr, Daikos G.L., Gkoufa A., Adamis G., Stefos A., Symbardi S., Chrysos G., Filiou E., Basoulis D., Mouloudi E., Galani L., Akinosoglou K., Arvaniti K., Masgala A., Petraki M., Papadimitriou E., Galani I., Poulakou G., Routsi C., Giamarellou H. (2021)
      Background: Infections caused by KPC-producing Klebsiella pneumoniae (Kp) are associated with high mortality. Therefore, new treatment options are urgently required. Objectives: To assess the outcomes and predictors of ...
    • The clinical significance of carbapenem-resistant Klebsiella pneumoniae rectal colonization in critically ill patients: From colonization to bloodstream infection 

      Kontopoulou K., Iosifidis E., Antoniadou E., Tasioudis P., Petinaki E., Malli E., Metallidis S., Vatopoulos A., Malisiovas N. (2019)
      Purpose. To highlight the clinical significance of carbapenem-resistant Klebsiella pneumoniae (CRKP) rectal colonization by examining the risk factors for CRKP rectal colonization and subsequent bloodstream infection (BSI) ...
    • Geographical variation in therapy for bloodstream infections due to multidrug-resistant Enterobacteriaceae: a post-hoc analysis of the INCREMENT study 

      Harris P.N.A., Pezzani M.D., Gutiérrez-Gutiérrez B., Viale P., Hsueh P.-R., Ruiz-Garbajosa P., Venditti M., Tumbarello M., Navarro-Francisco C., Calbo E., Akova M., Giamarellou H., Oliver A., Almirante B., Gasch O., Martínez-Martínez L., Schwaber M.J., Daikos G., Pitout J., Peña C., Hernández-Torres A., Doi Y., Pérez F., Tuon F.F., Tacconelli E., Carmeli Y., Bonomo R.A., Pascual Á., Paterson D.L., Rodríguez-Baño J., del Toro M.D., Gálvez J., Falcone M., Russo A., Karaiskos I., Trecarichi E.M., Losito A.R., García-Vázquez E., Gómez J., Roilides E., Iosifidis E., Pournaras S., Prim N., Navarro F., Mirelis B., Origüen J., Juan R.S., Fernández-Ruiz M., Almela M., de la Calle C., Martínez J.A., Morata L., Larrosa N., Puig-Asensio M., Bou G., Molina J., González V., Bermejo J., Rucci V., de Gopegui E.R., Marinescu C.I., Fariñas M.C., Cano M.E., Gozalo M., Paño-Pardo J.R., Mora-Rillo M., Gómez-Zorrilla S., Tubau F., Tsakris A., Zarkotou O., Antoniadou A., Poulakou G., Souli M., Lowman W., Virmani D., Torre-Cisneros J., Machuca I., Gracia-Ahufinger I., Azap Ö.K., Helvaci Ö., Sahin A.O., Cantón R., Pintado V., Bartoletti M., Giannella M., Peter S., Hamprecht A., Badia C., Xercavins M., Fontanals D., Jové E., ESGBIS/REIPI/INCREMENT Group (2017)
      We describe regional differences in therapy for bloodstream infection (BSI) caused by extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) or carbapenemase-producing Enterobacteriaceae (CPE). Patients (n = ...
    • ICU-Associated Gram-Negative Bloodstream Infection: Risk Factors Affecting the Outcome Following the Emergence of Colistin-Resistant Isolates in a Regional Greek Hospital 

      Karvouniaris M., Poulakou G., Tsiakos K., Chatzimichail M., Papamichalis P., Katsiaflaka A., Oikonomou K., Katsioulis A., Palli E., Komnos A. (2022)
      Intensive care unit patients may present infections by difficult-to-treat-resistant Gram-negative microorganisms. Colistin resurfaced as a last resort antibiotic for the treatment of multidrug-resistant Gram-negative ...
    • Incidence and Risk Factors for Blood Stream Infection in Mechanically Ventilated COVID-19 Patients 

      Mantzarlis K., Deskata K., Papaspyrou D., Leontopoulou V., Tsolaki V., Zakynthinos E., Makris D. (2022)
      It is widely known that blood stream infections (BSIs) in critically ill patients may affect mortality, length of stay, or the duration of mechanical ventilation. There is scarce data regarding blood stream infections in ...
    • Lessons from pathophysiology: Use of individualized combination treatments with immune interventional agents to tackle severe respiratory failure in patients with COVID-19 

      Dalekos G.N., Stefos A., Georgiadou S., Lygoura V., Michail A., Ntaios G., Samakidou A., Giannoulis G., Gabeta S., Vlychou M., Petinaki E., Leventogiannis K., Giamarellos-Bourboulis E.J., Gatselis N.K. (2021)
      Aims Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may lead to the development of severe respiratory failure. In hospitalized-patients, prompt interruption of the virus-driven inflammatory process ...
    • Molecular characteristics and predictors of mortality among Gram-positive bacteria isolated from bloodstream infections in critically ill patients during a 5-year period (2012–2016) 

      Papadimitriou-Olivgeris M., Kolonitsiou F., Karamouzos V., Tsilipounidaki K., Nikolopoulou A., Fligou F., Marangos M., Petinaki E., Spiliopoulou I. (2020)
      To identify the molecular characteristics of Gram-positive cocci isolated from blood cultures and clinical outcome among critically ill patients. This retrospective study was conducted in the general intensive care unit ...
    • Mutations conferring colistin resistance development in Acinetobacter baumannii clinical isolates 

      Dafopoulou, K.; Poulou, A.; Makris, D.; Hadjichristodoulou, C.; Tsakris, A.; Pournaras, S. (2013)
      The colistin resistance mechanisms in Acinetobacter baumannii are largely unknown. In the present study, we investigated the characteristics and the mechanisms of colistin resistance in two genetically indistinguishable ...
    • Outbreak of bloodstream infections because of Serratia marcescens in a pediatric department 

      Iosifidis, E.; Farmaki, E.; Nedelkopoulou, N.; Tsivitanidou, M.; Kaperoni, M.; Pentsoglou, V.; Pournaras, S.; Athanasiou-Metaxa, M.; Roilides, E. (2012)
      Background: Serratia marcescens can cause health care-associated infections. We herewith report the investigation and control of an outbreak of S marcescens bloodstream infections (BSI) in a general pediatric department. ...
    • A Predictive Model of Mortality in Patients With Bloodstream Infections due to Carbapenemase-Producing Enterobacteriaceae 

      Gutiérrez-Gutiérrez B., Salamanca E., de Cueto M., Pascual A., Rodríguez-Baño J., Hsueh P.-R., Viale P., Paño-Pardo J.R., Venditti M., Tumbarello M., Daikos G., Pintado V., Doi Y., Tuon F.F., Karaiskos I., Machuca I., Schwaber M.J., Azap Ö.K., Souli M., Roilides E., Pournaras S., Akova M., Pérez F., Bonomo R.A., Bermejo J., Oliver A., Almela M., Lowman W., Almirante B., Carmeli Y., Paterson D.L., Falcone M., Russo A., Giamarellou H., Trecarichi E.M., Losito A.R., García-Vázquez E., Hernández A., Gómez J., Iosifidis E., Prim N., Navarro F., Mirelis B., Origüen J., San Juan R., Fernández-Ruiz M., Larrosa N., Puig-Asensio M., Cisneros J.M., Molina J., González V., Rucci V., Ruiz de Gopegui E., Marinescu C.I., Martínez-Martínez L., Fariñas M.C., Cano M.E., Gozalo M., Mora-Rillo M., Navarro-San Francisco C., Peña C., Gómez-Zorrilla S., Tubau F., Tsakris A., Zarkotou O., Pitout J., Virmani D., Torre-Cisneros J., Natera C., Helvaci Ö., Sahin A.O., Cantón R., Ruiz P., Bartoletti M., Giannella M., Taconelli E., Riemenschneider F., Calbo E., Badia C., Xercavins M., Gasch E., Fontanals D., Jové E. (2016)
      Objective To develop a score to predict mortality in patients with bloodstream infections (BSIs) due to carbapenemase-producing Enterobacteriaceae (CPE). Patients and Methods A multinational retrospective cohort study ...
    • Rapid dissemination of colistin and carbapenem resistant Acinetobacter baumannii in Central Greece: Mechanisms of resistance, molecular identification and epidemiological data 

      Oikonomou O., Sarrou S., Papagiannitsis C.C., Georgiadou S., Mantzarlis K., Zakynthinos E., Dalekos G.N., Petinaki E. (2015)
      Background: Colistin-resistant/carbapenem-resistant Acinetobacter baumannii is a significant challenge for antibiotic treatment and infection control policies. Since 2012, in Central Greece an increase of colistin/pan- ...